Antistress Activity of Nyctanthes arbor tristis fruits in rats

نویسندگان

  • Shalini Tripathi
  • Pushpendra K. Tripathi
چکیده

Nyctanthes arbor-tristis, (Fam. Oleaceae) is commonly known as Parijatham, Harsinghar and Night Jasmine. Different parts of Nyctanthes arbor-tristis are known to possess various ailments by rural mainly tribal people of India along with its use in Ayurveda, Sidha and Unani systems of medicines. They have also been investingated for various pharmacological actions. Water soluble fraction of ethanolic extract of fruits of Nyctanthes arbor-tristis Linn (NATF) was pharmacologically validated for its antistress properties in normal and stress induced experimental animals. Extract was given orally at different dose levels (250 and 500 mg/kg p.o.) once daily for seven consecutive days. For the evaluation of antistress activity, groups of rats (n = 6) were subjected to forced swim stress one hour after daily treatment of NATF. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as non-invasive biomarkers to assess the antistress activity. The 24 h urinary excretion of vanillylmandelic acid (VMA) and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The NATF observed under above parameters showed positive antistress activity.

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تاریخ انتشار 2013